KPV (lysine-proline-valine)

KPV peptide is a short, three–amino acid fragment (lysine–proline–valine) derived from alpha-melanocyte-stimulating hormone. It is studied for its anti-inflammatory and immune-modulating properties, primarily by reducing pro-inflammatory cytokines and influencing pathways like NF-κB.

• Gut Health: Reduces inflammation in conditions like ulcerative colitis, Crohn’s disease, and aids in repairing intestinal barrier integrity.

• Skin Care: Used in creams or serums to treat acne, chronic redness, and eczema by lowering inflammation and promoting tissue repair.

• Systemic Inflammation & Infection: Acts as a natural antimicrobial against bacteria and fungi, while inhibiting pro-inflammatory cytokines such as TNF and IL-1.

• Mast Cell Stabilization: Helps reduce histamine-mediated symptoms, useful for MCAS (Mast Cell Activation Syndrome).

• Lys-Pro-Val

• Alpha-MSH

• Melanocortin-derived tripeptide

• There are no long-term human studies, and these peptides are not approved by the FDA, with potential risks unknown.

• They are often sourced through specialized, clinician-guided, or anti-aging, clinics.