Mots-c

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded in mitochondrial DNA that acts as a signaling molecule to regulate metabolism and promote cellular homeostasis, particularly under stress. It acts as an exercise-induced regulator that improves glucose utilization, insulin sensitivity, and physical performance while reducing obesity and age-related declines.

• It mimics exercise and fasting, activating the AMPK pathway, which helps muscle cells use glucose more efficiently.

• Research suggests it could treat obesity, type 2 diabetes, and age-related muscle loss.

• Mitochondrial-derived peptide MOTS-c

• mtDNA-encoded peptide MOTS-c

• Humanin-like mitochondrial peptide

• There are no long-term human studies, and these peptides are not approved by the FDA, with potential risks unknown.

• They are often sourced through specialized, clinician-guided, or anti-aging, clinics.